| abstract |
The compounds of structural formula (I) are androgen receptor (AR) modulators in a tissue selective manner. These compounds, alone or in combination with other active agents, are useful to enhance reduced muscle tone, and also include osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, fractures Bone damage after bone reconstruction surgery, sarcopenia, vulnerability, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, regeneration Aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, For conditions caused by androgen deficiency or androgen administration, such as muscular dystrophy, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure and autoimmune diseases Useful in the treatment of conditions which may be improved Ri. |