| abstract |
The present invention relates to novel bicyclononene derivatives and their use as active ingredients in the manufacture of pharmaceutical compositions. The present invention also relates to methods for the manufacture of compounds, pharmaceutical compositions comprising one or more of the compounds, and related aspects including their use as renin inhibitors in particular. The present invention relates to a low molecular weight renin inhibitor with non-peptidic properties. The tissue renin-chymase system is activated to regulate blood pressure that can cause pathophysiologically altered local functions such as kidney, heart, and blood vessel remodeling, atherosclerosis, and possibly restenosis A long-acting orally active renin inhibitor active in out-of-range signs is described. The present invention then describes these non-peptide renin inhibitors of formula (I). |