abstract |
The present invention relates to blocking, suppressing, reducing, antagonizing or neutralizing the activity of IL-17F, IL-17A or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines involved in inflammatory processes and human diseases. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention relates to soluble ZcytoR14 and anti-ZcytoR14 antibodies and binding partners, and methods of antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners Include. |