| abstract |
Compounds having the following formula (I): wherein R 1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo (lower) alkyl, cyclo (higher) alkyl, cyclo (lower) alkyl (lower) Alkyl, cyclo (higher) alkyl (lower) alkyl, cyclo (lower) alkenyl (lower) alkyl, aryl-fused cyclo (lower) alkyl, lower alkoxy, acyl, aryl, ar (lower) alkoxy, ar (lower) alkyl, Heteroal (lower) alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl (lower) alkyl, which may be substituted with one or more suitable substituents, wherein R 2 is hydrogen or lower alkyl And X is arylene, heteroarylene, cycloalkylene, heterocycloalkyl. Rene or aryl-fused cycloalkylene, Y is arylene or heteroarylene, which may be substituted with one or more suitable substituents, Z is a lower alkenylene, which is a lower alkyl or Optionally substituted with halogen) or a salt thereof. This compound is useful as a histone deacetylase inhibitor. [Selection figure] None |