| abstract |
A novel member of the RAET1 / ULBP family of proteins (RAET1G) has been identified and characterized and shows that it binds to the UL16 and NKG2D receptors with high affinity. RAET1G shows limited expression in normal tissues, but is expressed at high levels in tumors and appears to be spliced in a different manner in cancer cells to produce soluble proteins. RAET1G is also up-regulated in inflammatory diseases such as celiac disease. RAET1G can be used as a novel marker for cancer states and disease states including inflammatory diseases. |