| abstract |
Pharmaceutical compositions comprising cell surface receptor isoforms, including receptor tyrosine kinase isoforms and receptor tyrosine kinase isoforms are provided. Chimera comprising a cell surface receptor comprising a portion, eg, an extracellular domain from one cell surface receptor or a portion thereof, and a second portion derived from a second cell surface protein, particularly a portion encoded by an intron As well as conjugates. Isoforms modulate the activity of cell surface receptors. Methods of identifying and preparing cell surface receptor isoforms, including receptor tyrosine kinases, are provided. Also provided are methods of treatment using cell surface receptor isoforms. [Selection figure] None |