| abstract |
In order to prevent the formation of scar tissue and / or adhesions during wound or surgical site healing, the present invention provides a cytostatic anti-proliferative drug between internal body tissues, either alone or in combination with other drugs. Various devices and methods that are deployed are described. Particular devices for accomplishing this administration include, but are not limited to, permanent implants or biodegradable materials with antiproliferative drugs such as sirolimus attached. These antiproliferative agents can be used in combination with other drugs including but not limited to antiplatelet agents, antithrombotic agents, or anticoagulants. The present invention also contemplates methods for reducing adhesion formation at the scar tissue and / or adhesion or anastomosis site. In particular, cytostatic antiproliferative drugs are administered in arteriovenous shunt anastomoses in patients with end stage renal disease. |