| abstract |
The present invention discloses inhibitors of gamma secretase of formula I: wherein L is —O—, —N (R 6 ) —, —S—, —S (O) —, or —S. (O 2) - a is; R 1 is aryl and is selected from the group consisting of heteroaryl; and Y is, -NR 8 R 9, -N ( R 6) - (CH 2) b -NR 8 R 9 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is of formula II and formula III Selected from the group consisting of: one or more compounds of formula I, or formulations containing such compounds, for example in treating Alzheimer's disease Can be useful. |