http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008505055-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2004-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008505055-A |
| titleOfInvention | Novel potassium channel modulator peptide |
| abstract | A novel 13-residue peptide, Mo1659, was isolated from the venom of the carnivorous mussel, scabbard potato. HPLC fractionation of the venom extract produced a strong UV-absorbing fraction with a mass of 1659 Da. De novo sequencing was performed using matrix-assisted laser desorption ionization and electrospray MS / MS methods along with analysis of proteolytic fragments and the amino acid sequence FHGGSWYRFPWGY-NH 2 was successfully obtained. This was further confirmed by comparison with chemically synthesized peptides and sequencing by the conventional Edman method. Mo1659 has an overwhelmingly large number of aromatic residues, and has a unique sequence in which nonpolar aliphatic residues such as Ala, Val, Leu, and Ile do not exist. Mo1659 has no disulfide bonds, is distinct from conotoxins, and has no sequence similarity with any of the acyclic peptides previously isolated from mussel venom. Electrophysiological studies on the effect of Mo1659 on currents measured in dorsal root ganglion neurons suggest that the peptide targets inactivated potential-type potassium channels. |
| priorityDate | 2004-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.