| abstract |
The present invention relates to a method for producing a polymer support material for solid phase synthesis, in particular for peptide synthesis. Carbohydrate-based (meth) acrylamide derivatives (which may contain other protecting groups) are polymerized by suspension polymerization in the aqueous phase, optionally with the addition of pore-forming additives, and then protected. The group is completely or partially cleaved. Therefore, its form (particle size, porosity), degree of crosslinking and wettability in aqueous and organic solvents can be adjusted to the desired method, and the reactive group can be used to fix anchor groups and protecting groups. Polymer carriers that provide multiple opportunities can be obtained. The hydroxyl group of the polymer support is activated by the general method of solid phase synthesis. [Selection figure] None |