http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008504338-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2005-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008504338-A |
| titleOfInvention | Novel 2-substituted estra-1,3,5 (10) -trien-17-ones as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 |
| abstract | The present invention relates to the following general formula I: [Wherein R 2 represents a saturated or unsaturated C 1 -C 8 -alkyl group, C 1 -C 5 -alkyloxy group, aralkyl group or alkylaryl group, a group —O—CnFmHo (where n = 1 , 2, 3, 4, 5 or 6, m ≧ 1 and m + 0 = 2n + 1), or the group CH 2 XY (where X represents an oxygen atom and Y is an alkyl group having 1 to 4 carbon atoms) As well as a halogen atom or a nitrile group, R 13 is a hydrogen atom or a methyl group, R 16 is a hydrogen atom or a fluorine atom, Z is an oxygen atom or a sulfur atom, R 3 and R 5 are each independently an α- or β-position hydrogen atom, and each R 4 and R 6 is independently an α- or β-position hydrogen atom, C 1 -C 5- alkyl group, C 1 -C 5 - alkyl group, C 1 -C 5 - an acyl group or a hydroxy group, or an aralkyl group or alkylaryl group R 3 and R 4 together represent an oxygen atom, R 5 and R 6 together represent an oxygen atom, each of R 7 and R 8 are hydrogen atom, or together represent a CH 2 group] And to the novel 2-substituted estra-1,3,5 (10) -trien-17-one represented. Pharmaceutically acceptable salts of said compounds, said compounds in the form of drugs useful for preventing and treating estrogen-dependent diseases and being affected by inhibiting 17β-hydroxysteroid dehydrogenase type 1 The production and use of is also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4871274-B2 |
| priorityDate | 2004-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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