abstract |
The present invention is directed to novel indazole carboxamide derivatives. In particular, the present invention provides compounds of formula (I) [Wherein R1 and Z are as described herein] And the pharmaceutically acceptable salts thereof. The compounds of the present invention are inhibitors of IKK2 and are useful in the treatment of disorders associated with inappropriate IKK2 (also referred to as IKKβ) activity, such as rheumatoid arthritis, asthma and COPD (chronic obstructive pulmonary disease). Accordingly, the present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention. The present invention is still further directed to methods of inhibiting IKK2 activity and related disorders thereof using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. |