| abstract |
The present invention relates to compounds that are estrogen receptor modulators and derivatives thereof, their synthesis, and their use. The compounds of the present invention are estrogen receptor ligands and are therefore bone loss, fracture, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroma, hot flash, LDL Elevated cholesterol levels, cardiovascular disease, cognitive impairment, cerebral degenerative disorder, recurrent stenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, anxiety, depression due to estrogen deficiency, inflammation, inflammatory bowel disease It would be useful for the treatment or prevention of various conditions related to estrogen function, such as sexual dysfunction, hypertension, retinal degeneration, and cancer, particularly breast cancer, uterine cancer, prostate cancer. |