| abstract |
The present invention provides antibodies and functional fragments comprising recombinant antigen binding regions and such antigen binding regions specific for CD38, but plays an essential role in various injuries and conditions. These antibodies can therefore be used, for example, to treat hematological malignancies, such as multiple myeloma. The antibodies of the invention can be used both in the diagnostic field and to investigate the role of CD38 in the progression of injury associated with malignancy. The invention also provides a kit comprising a nucleic acid sequence encoding said antibody, a vector comprising said sequence, a pharmaceutical composition and instructions for use. The invention also provides novel isolated epitopes of CD38 and methods of use thereof. |