| abstract |
The present invention describes compounds and pharmaceutical compositions useful as ubiquitin factor inhibitors (particularly ubiquitin ligase inhibitors). The compounds and pharmaceutical compositions of the invention are useful as inhibitors of biochemical pathways (eg, signal transduction systems) in organisms that involve ubiquitin binding. The invention also encompasses the use of the compounds and pharmaceutical compositions of the invention to treat conditions that require inhibition of ubiquitin binding. Furthermore, the present invention includes a method of inhibiting ubiquitin binding in a cell, the method comprising contacting a cell in which inhibition of ubiquitin binding is desired with a compound or pharmaceutical composition of the present invention. In particular, these compounds and pharmaceutical compositions are useful for inhibiting the ubiquitin ligase activity of TRAF6. |