| abstract |
[Chemical 19] Compounds of formula (I) and any tautomers thereof (wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl: R ′ is hydrogen, C 1- C 4 alkyl, C 1 -C 3 alkoxy, halogen, trifluoromethyl or OCH x F y ; R ″ is hydrogen, fluoro or chloro, but only when R ′ is fluoro or chloro. R ″ is fluoro or chloro; R 3 is hydrogen or C 1 -C 5 alkyl; R 4 is hydrogen, CH 2 OCOC (CH 3 ) 3 , a pharmaceutically acceptable inorganic cation or An organic cation, or COR 4 ′, wherein R 4 ′ is C 1 -C 5 alkyl, phenyl, benzyl or phenethyl; R 7 is methyl or ethyl; one of A and B is sulfur In And the other is C-R 2; when A is S, R 2 is selected from hydrogen and methyl, provided that only when R 3 is not hydrogen, R 2 is methyl; and, B is S When R 2 is hydrogen). A pharmaceutical composition comprising a compound of formula (I), a malignant tumor or a method of treating a disease resulting from autoimmunity or pathological inflammation. |