| abstract |
The present invention relates to THAP family genes and proteins comprising a THAP domain and their use in the diagnosis and treatment of diseases and the identification of molecules for the treatment of diseases. The present invention also includes the use of THAP-type chemokine binding agents, such as THAP-family proteins, as nuclear receptors for chemokines, and methods for modulating (stimulating or inhibiting) transcription, cell proliferation, and cell differentiation, and THAP-chemokine interactions. It also relates to a method for identifying a compound that modulates an action. |