| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-62 |
| filingDate |
2005-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2008-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2008501741-A |
| titleOfInvention |
Multilayer controlled release methylphenidate pellets |
| abstract |
The present invention relates to a type of controlled release multilayer methylphenidate pellet that does not need to be combined with another type of pellet. It is possible to maintain a therapeutic concentration in plasma for 12 hours with once daily dosing, avoiding repeated dosing throughout the day. Controlled release multilayer pellets are an inert core, a first layer containing methylphenidate and an acid buffer system, a protective layer, and a layer of ethylcellulose that functions to control the sustained release of most methylphenidate. And a second methylphenidate layer responsible for immediate release within 1 hour of administration. The weight ratio between methylphenidate and ethylcellulose present in the first active layer is 1.40: 1 to 1.90: 1. The multi-layer pellet may have an outer coating to protect it from erosion during processing. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101334947-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013523804-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017532363-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017128614-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012508228-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015083599-A |
| priorityDate |
2004-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |