| abstract |
The invention consists of a heptapeptide pattern of the sequence X 1 X 2 X 3 X 4 X 5 X 6 X 7 and a transduction domain, or a hepta peptide pattern of the sequence X 1 X 2 X 3 X 4 X 5 X 6 X 7 includes, that a chimeric polypeptide, said amino acid X 7 is located between 5 and 35 amino acids of the C-terminus of the polypeptide, and that the domain (b) is located at the C-terminus with respect to the pattern (a) In an interacting polypeptide characterized by The present invention relates to screening methods for identifying interacting polypeptides that can modify the phenotype of cells and the use of said interacting polypeptides for phenotypic screening or therapeutic purposes. Finally, the present invention relates to interacting polypeptides that can modify the function of HIV-1 Rev viral proteins. |