| abstract |
The present invention provides an aggrecanase protein and nucleotide sequences encoding the same, a method for producing the same, an aggrecanase enzyme inhibitor for the treatment of symptoms characterized by degradation of aggrecan, and a method for developing an antibody against the enzyme. An isolated DNA molecule comprising a DNA sequence having a specific sequence, an aggrecanase protein encoded thereby, and a method for producing a human aggrecanase protein by culturing and purifying a host cell transformed with the DNA molecule, Inhibitors of the aggrecanase activity and antibodies thereto. [Selection figure] None |