| abstract |
Disclosed is a pharmaceutical for treating or preventing hypertension, which is a crystalline solid and excellent in heat stability. (R) -2-amino-1,4-dihydro-6-methyl-4- (3-nitrophenyl) -3,5-pyridine, which is a pharmaceutical conventionally obtained as an amorphous solid Dicarboxylic acid 3- (1-diphenylmethylazetidin-3-yl) ester A medicament containing a crystal of hydrochloride or hydrobromide of 5-isopropyl ester (following formula) as an active ingredient. In particular, in the dihydrochloride hydrate of the compound, the interplanar spacing is 17, 7.1, 4.9, 4.3, 3.9, and in the powder X-ray diffraction pattern obtained by irradiation with copper Kα rays. A medicine containing a crystal having a major peak at 3.5 angstroms as an active ingredient is preferable. [Selection figure] None |