abstract |
In detecting chromosomal abnormalities, gene rearrangements at a plurality of loci are simultaneously detected. In situ hybridization using highly complex nucleic acid probes consisting of a mixture of labeled heterologous nucleic acid fragments, each complementary to a locus of target chromosomal material in a region containing each suspicious gene rearrangement To detect adjacent genetic syndromes. A nucleic acid probe consists of a sequence that is substantially homologous to a nucleic acid sequence that exhibits the properties of multiple components of an adjacent genetic syndrome. Suspected genetic abnormalities include acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and Down's syndrome. [Selection] Figure 8 |