| abstract |
Provided is a method for producing a microcapsule having a uniform form and having no cohesiveness using a solvent having no toxicity problem by a simple and gentle method. To produce microcapsules containing peptides, proteins or other water-soluble biologically active substances as active substances, composed of biodegradable polymers or copolymers and having a uniform morphology ,-A hydroxycarboxylic acid polyester or a block copolymer composed of a hydroxycarboxylic acid polyester and polyethylene glycol is dissolved in a solvent or solvent mixture that does not contain halogen, and 1 part is miscible with water. Disperse the active substance buffer having a pH value of 6.0 to 8.0, and subsequently add an aqueous solution containing a surfactant or a mixture of surfactants to the W / O emulsion, and finally A method for producing a microcapsule, wherein a solvent or a solvent mixture is removed using a usual method and method. [Selection figure] None |