Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75d1a4caed60a9316608ed9c231546c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8cdfbc70d9776e1ea4502b21128b30c |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2005-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7e1c6dfd7b6789ffc18a322f2551dcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3e6f3ff63af101b81af569a817e3780 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de4f724ab9995b161171ab09c880db6f |
publicationDate |
2008-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2008273842-A |
titleOfInvention |
Preventive agent for graft loss and screening method thereof |
abstract |
A prophylactic agent for graft loss and a screening method thereof are provided. A preventive agent for graft loss comprising an NKT cell ligand such as α-galactosylceramide is provided. If the prophylactic agent of the present invention is used, it is possible to prevent graft loss due to islet transplantation in clinical practice, which can contribute to the improvement of transplantation efficiency. Also provided is a screening method for a compound for preventing / treating graft loss, which comprises selecting a compound capable of suppressing NKT cell activation, IFN-γ production of CD11b + cells, and the like. By using the screening method of the present invention, it is possible to create a preventive / therapeutic agent for early graft loss by a new mechanism. [Selection figure] None |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014069655-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012025673-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014069655-A1 |
priorityDate |
2005-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |