| abstract |
A novel phenylenediamine derivative having a new pharmacological action of a phenylenediamine derivative is synthesized, and an intraocular pressure lowering agent having the pharmacological action found is provided. An intraocular pressure-lowering agent comprising as an active ingredient at least one selected from the group consisting of a compound represented by formula (1) or a salt thereof. In the formula, ring A is thiophene, pyridine, etc., R 1 and R 2 are hydrogen atom, lower alkyl group, lower alkenyl group, lower alkynyl group, lower cycloalkyl group, aryl group, hydroxy group, lower alkoxy group, etc. 1 and R 2 together may form a nitrogen-containing heterocyclic ring which may have a substituent, R 3 is a halogen atom, a lower alkyl group, a hydroxy group, etc., m is 0, 1 or 2 Indicates. [Selection figure] None |