| abstract |
Synthetic studies of a novel pyridinecarboxylic acid (2-aminophenyl) amide derivative having a novel urea structure and the pharmacological action of the derivative are found. A compound represented by formula (1) or a salt thereof. In the formula, R 1 and R 2 are a hydrogen atom, a lower alkyl group, etc., R 3 is a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, a carboxy group, a lower alkoxycarbonyl group, —OCONR a R b , —NR c R d, etc., R 4 and R 5 are halogen atoms, lower alkyl groups, hydroxy groups, lower alkoxy groups, etc., R a and R b are hydrogen atoms, lower alkyl groups, lower cycloalkyl groups, aryl groups, A heterocyclic group, R c and R d are a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, an aryl group, X is a lower alkylene group, Y is a single bond, a lower alkylene group, W 1 -W 2 is N- C, C—N, l and m represent 0, 1, 2 or 3. [Selection figure] None |