| abstract |
[PROBLEMS] To prevent cracking and powdering when a drug (or a mixture of drug and excipient) is coated on a surface in a fluid state to form a preparation, and without separately coating a basic substance. It is possible to stably coat chemical (acid etc.) labile drugs (for example, the anti-ulcer drug omeprazole), and also has high disintegration (solubility) in the digestive tract after oral administration as a preparation. A spherical core particle for pharmaceutical preparation is provided. The particle size distribution is 5% or less (including 0%) of particles less than 100 μm, 90% or more of particles less than 100 μm, 90% or more of particles less than 500 μm, 5% or less (including 0%) of particles of 500 μm or more, and A spherical core particle for pharmaceutical preparation comprising spherical magnesium hydroxide particles having a particle hardness of 200 g / mm 2 or more. [Selection figure] None |