| abstract |
An object of the present invention is to provide a transdermal administration device capable of continuously administering an amount of bisoprolol effective for treatment or prevention into a living body, with reduced skin irritation at the time of application, in particular, reattachment. A transdermal administration device for bisoprolol of the present invention comprises a support and a pressure-sensitive adhesive layer laminated on one side of the support. The pressure-sensitive adhesive layer contains bisoprolol and is applied to the skin. The maximum bisoprolol release rate immediately after 24 hours is 30 μg / cm 2 / hour or less, and the bisoprolol release rate is 10 μg / cm 2 / hour or less immediately after skin application until 24 hours. It is characterized by. This not only suppresses skin irritation caused by bisoprolol, but also eliminates the possibility of side effects such as bradycardia and dizziness due to excessive hypotension, thereby ensuring sufficient safety. [Selection] Figure 1 |