| abstract |
【Task】 In the continuous fermentation method, microorganisms and cells are filtered through a separation membrane, the product is recovered from the filtrate, and at the same time, the filtered microorganisms and cells are refluxed to the fermentation broth to improve the microorganisms and cell concentration in the broth, and The present invention provides a method for producing a chemical product by a continuous fermentation method that maintains high substance productivity by maintaining a high level. [Solution] The fermentation broth of microorganisms or cultured cells is filtered through a separation membrane, the product is recovered from the filtrate, and the unfiltered liquid is retained or refluxed in the fermentation broth, and the fermentation raw material is used as the fermentation broth. In the continuous fermentation to be added to the above, a hollow fiber porous membrane having pores with an average pore diameter of 0.01 μm or more and 5 μm or less is used as the separation membrane, and the transmembrane pressure difference is set in the range of 0.1 kPa or more and less than 200 kPa. A method for producing a chemical product by continuous fermentation, characterized by subjecting to filtration. [Selection] Figure 1 |