| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate |
2007-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_021bf9e4fb6f327fd320976eb0b139c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d9cb29d77c9d38ea34786b213402555 |
| publicationDate |
2008-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2008231062-A |
| titleOfInvention |
Manufacturing method of mirtazapine |
| abstract |
[PROBLEMS] To provide mirtazapine which can be safely used as a pharmaceutical product with high purity from a reaction solution obtained by cyclizing 2- (4-methyl-2-phenylpiperazin-1-yl) pyridine-3-methanol with concentrated sulfuric acid by a simple method. A method of isolation is provided. A reaction solution obtained by cyclization of 2- (4-methyl-2-phenylpiperazin-1-yl) pyridine-3-methanol with concentrated sulfuric acid is diluted with water and then made alkaline in the presence of propanol. A method for producing mirtazapine, comprising extracting mirtazapine with propanol and then crystallizing mirtazapine from the extract. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020007243-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017088564-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7018840-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017088565-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017039659-A |
| priorityDate |
2007-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |