| abstract |
An object of the present invention is to provide a complex having a useful function based on the action of a functional molecule and capable of exerting an RNA interference effect on a target gene. A complex of a modified peptide nucleic acid and a double-stranded RNA, the double-stranded RNA comprising a base sequence complementary to a target sequence in a target gene, and the sense strand It is a double-stranded RNA having an antisense strand RNA having a complementary base sequence and capable of suppressing the expression of the target gene. The double-stranded RNA includes at least the sense strand RNA and the antisense strand RNA. Single-stranded DNA is bound to one end directly or via a linker, and the modified peptide nucleic acid is a functional molecule bound to a peptide nucleic acid directly or via a linker. The modified PNA / RNA complex, wherein the peptide nucleic acid has a sequence capable of hybridizing to the single-stranded DNA and is hybridized to the single-stranded DNA. [Selection figure] None |