| abstract |
PROBLEM TO BE SOLVED To provide a library of polyketides, other natural products, compounds and individual novel compounds. Isolation of novel FKBP-ligand analogues and potential uses, and host cells producing these compounds. In particular, efficient transformation of recombinant cells in which FKBP analog-producing strains and clone genes or gene cassettes are expressed to produce new compounds such as polyketide (especially rapamycin) FKBP-ligand analogs. Methods, and their preparation, and the means used therein (eg, nucleic acids, vectors, gene cassettes, and genetically modified strains). [Selection figure] None |