| abstract |
A tool for elucidating the role of a sugar chain in vivo is provided. SOLUTION: At least part of the EXTL2 gene, one of the tumor suppressor gene families, is deficient on the chromosome, and the EXTL2 gene does not function normally, and the amount of heparan sulfate or chondroitin sulfate synthesized is increased compared to the wild type And non-human animals with enhanced cancer metastasis. Moreover, after administering cancer cells to the animal, a cancer metastasis inhibitor candidate substance is administered, and the inhibitor is screened. [Selection figure] None |