| abstract |
The present invention relates to a novel compound having immunomodulatory activity, a synthetic intermediate useful for the production of the novel compound, and particularly a macrolide immunomodulator. Providing semisynthetic analogs of rapamycin, methods for their preparation, pharmaceutical compositions containing such compounds, and methods of treatment using them. Novel macrolide compounds, semisynthetic analogs of rapamycin, and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, methods for preparing the compounds of the present invention, intermediates useful in these methods Body, pharmaceutical composition and method of treating immunomodulatory diseases. [Selection figure] None |