| abstract |
The present invention provides identification, isolation of polypeptides having WW domains or functional equivalents thereof, and various uses of these polypeptides. Also provided are various peptide recognition units that bind to the WW domain. A novel polypeptide having a WW domain and a DNA sequence encoding the same. Providing a method for identifying these polypeptides by a sequence-independent means (ie, independent of the primary sequence of the searched polypeptide) and a functional screening method based on the recognition unit. A variety of applications of the method and identified polypeptides can be used in assay kits for drug discovery, modification and refinement. [Selection figure] None |