http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008157807-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9019c0ce5cb7b82c85e121f6cac86dce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9df90d7822cc480ce12c480f4089e229 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2006-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bc2adb86932f874fc9e05226298f749 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d78b53d785f87e9ecacfc501df3db9b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03b3efafcfb9184cc727627c4b6106f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ad553c520c3a1c94b8fd643a2a71731 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab3288d8414c47a2493b52a8d25c1677 |
| publicationDate | 2008-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008157807-A |
| titleOfInvention | Drug screening method |
| abstract | [PROBLEMS] To determine the three-dimensional structure of a complex of FFRP and a plurality of ligands having different effects on their association with high resolution and high precision, and to compare and analyze both structures, thereby allowing mutual interaction between FFRP and a ligand. Details of the action are elucidated, and a method for designing or screening a drug that controls FFRP-mediated metabolism, growth or infection of microorganisms is provided. In a target FFRP sequence having 30% or more homology with the FFRP DM1 amino acid sequence shown in SEQ ID NO: 1, 15, 33, 35, 39, 56, 57, 61, 69 of the FFRP DM1 amino acid sequence, Identifying an amino acid residue at a position corresponding to 1 or 2 or more selected from positions 70, 71, and 75, based on the three-dimensional structure information of the amino acid residue, or the interaction between the amino acid residue and a candidate substance, FFRP ligand design or screening method characterized by determining target FFRP ligand candidates, and design of a drug that controls at least one or more selected from metabolism, growth and infection of microorganisms using the method or Screening method. [Selection] Figure 1 |
| priorityDate | 2006-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.