abstract |
Disclosed is a novel semi-synthetic macrolide having immunomodulatory activity and minimal side effects. A specific site of rapamycin is converted to a specific substituent to give a novel semi-synthetic macrolide. It has immunomodulatory action, rejection by organ transplantation, chronic indirect rheumatism, systemic lupus erythematosus, chronic lymphocytic thyroiditis (Hashimoto's disease), multiple sclerosis, myasthenia gravis, type I diabetes, uveitis, It is effective for autoimmune diseases such as allergic encephalomyelitis and glomerulonephritis. [Selection figure] None |