| abstract |
The present invention provides a novel compound having a Rho kinase inhibitory action and useful as a therapeutic agent for eye diseases such as glaucoma, and a pharmaceutical composition containing the compound. A compound represented by the general formula [I] and a pharmaceutical composition containing the compound. (Wherein ring X is a benzene ring or pyridine ring; R 1 and R 2 are H or alkyl; R 3 and R 4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy; , Cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc .; R 5 is a halogen atom, H, OH, alkoxy, aryloxy, alkyl, or Represents aryl, and each group may have a substituent.) [Selection figure] None |