| abstract |
The present invention provides a key intermediate in the synthesis of amino-substituted N, N′-bridged bisindolylmaleimide compounds useful as pharmaceuticals. A compound represented by the following formula: (Wherein R1 is an O-tosyl group.) The compounds are useful for preparing N, N'-bridged bis-indolylmaleimide compounds in high yield without undesirable toxic impurities. The compounds are also useful as isozyme-selective PKC inhibitors and are useful in the treatment of conditions related to diabetes and its complications, ischemia, inflammation, central nervous system disorders, cardiovascular diseases, skin diseases and cancer. It is. [Selection figure] None |