| abstract |
Disclosed is a pharmaceutical composition that reduces the level of TNFα in a mammal. A pharmaceutical composition for inhibiting TNFα comprising an effective amount of a compound having the following formula to inhibit TNFα. The novel nitriles are inhibitors of tumor necrosis factor α and phosphodiesterase and can be used to overcome vicious fluids, endotoxic shock, retroviral replication, asthma, and inflammatory conditions. A specific embodiment is 3-phthalimido-3- (3 ′, 4′-dimethoxyphenyl) propionitrile. [Selection figure] None |