| abstract |
Disclosed is a novel substance that inhibits the formation of a protein polymer by a polyglutamine sequence, suppresses neuronal cell death in polyglutamine diseases such as MJD, and exhibits a therapeutic effect. A polypeptide comprising the amino acid sequence of a), b) or c) below: a) a specific amino acid sequence; b) a partial amino acid sequence of the specific amino acid sequence; c) an amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence of a) or b), And a polypeptide having a polyglutamine aggregate formation inhibitory activity. The polypeptide can remarkably inhibit aggregation of a protein polymer having a polyglutamine sequence, particularly Ataxin-3 having an abnormal polyglutamine sequence, and can be used as a therapeutic agent for polyglutamine disease, particularly MJD. . [Selection figure] None |