| abstract |
A STAT6 activation inhibitor that accurately inhibits STAT6 activation is provided. The following general formula (1) [Wherein, R 1 represents a hydrogen atom, a halogen atom, a linear or branched C 1 -C 6 alkyl group, a linear or branched C 1 -C 6 alkoxy group, a nitro group, etc., and R 2 represents A hydrogen atom, a pyrazolyl group which may be substituted with a phenyl group, and the like, and R 3 , R 4 and R 5 may be the same or different, and a hydrogen atom, a halogen atom, a linear or branched C 1 to C 6 represents an alkyl group, a linear or branched C 1 -C 6 alkoxy group, a hydroxyl group, an amino group, a linear or branched C 1 -C 6 alkylamino group, and X represents N or the following formula (6 ) N + R 10 · Y − (6) [wherein R 10 represents a linear or branched C 1 to C 6 alkyl group, and Y − represents an anion. ] Is shown. ] The 2-phenylbenzimidazole derivative represented by these, its salt, or those solvates are used as an active ingredient. [Selection figure] None |