| abstract |
An effective method for producing a substituted aryllactic acid-containing cyclodepsipeptide is provided. SOLUTION: 4-Nitrophenyl lactic acid is added under aseptic conditions to a main culture solution of a fungal strain Mycelia sterlia, a species belonging to the species Agonmycetales, and the fermentation is continued. By extraction and purification, or by adding a substrate such as leucine, lactic acid, ATP, S-adenosyl-L-methionine, 4-nitrophenyl lactic acid to the enzyme preparation isolated from the fungal strain and reacting in vitro, It consists of a novel process for the production of substituted aryllactic acid-containing cyclodepsipeptides having 24 ring atoms. [Selection figure] None |