| abstract |
An object of the present invention is to provide a novel death domain-containing receptor 5 (DR5) protein. The present invention provides death domain-containing receptor 5 (DR5) protein that is a member of the tumor necrosis (TNF) receptor family and binds to TRAIL. In particular, an isolated nucleic acid molecule encoding a human DR5 protein is provided. DR5 polypeptides are also provided, and vectors, host cells, and recombinant methods for producing them are also provided. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. [Selection figure] None |