| abstract |
The vascular endothelium releases various vasoactive substances such as endothelin (ET), which is a vasoconstrictive peptide derived from the endothelium. Thienyl-, furyl- and pyrrolyl-sulfonamides; pharmaceutically acceptable salts of sulfonamides; salts and formulations of the sulfonamides; and endothelin peptides using the formulations and sulfonamides Methods of modulating or altering the activity of are provided. Specifically, formulations of sodium salts of N- (isoxazolyl) thienylsulfonamides, N- (isoxazolyl) furylsulfonamides and N- (isoxazolyl) pyrrolylsulfonamides are provided. A process for the production of an alkali metal salt of a hydrophobic sulfonamide is provided. The method includes dissolving a free sulfonamide in an organic solvent in the presence of a saturated alkali metal salt solution and recovering the produced sulfonamide salt from the organic solvent. [Selection figure] None |