| abstract |
[PROBLEMS] To reduce the antigenicity, confer pepsin resistance, prolong the life span of the body, a complex of non-peptidic hydrophilic polymer with high clinical usefulness and lactoferrin, and constant biological activity of natural lactoferrin Provided is a production and purification method for producing a large amount of a lactoferrin complex, which is retained in proportion and has clinical utility superior to natural lactoferrin in a short time. A method for producing a biologically active complex of a branched non-peptide hydrophilic polymer and lactoferrin, comprising a reaction solution containing lactoferrin and a branched non-peptide hydrophilic polymer. The process characterized by including the process made to react on the conditions of pH 8-10. [Selection figure] None |