| abstract |
To provide a safe and effective approach to enhance the immunogenicity of a wide range of antigens. A composition comprising a submicron oil-in-water emulsion and a selected antigen that is trapped in or adsorbed to the biodegradable microparticles. (A) 4-5% w / v squalene, 0.25-0.5% w / v Tween 80®, and 0.5% w / v Span 85®, and required N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2- (1′-2′-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy-ethylamine, submicron An oil-in-water emulsion of (b), and (b) trapped in poly (D, L-lactide-co-glycolide) microparticles or adsorbed on poly (D, L-lactide-co-glycolide) microparticles, A composition comprising a selected antigen. [Selection figure] None |