| abstract |
Disclosed is a mutant AD4 protein associated with Alzheimer's disease. An antibody that specifically binds to the mutant AD4 protein of (a) or (b) below. (A) A protein comprising an amino acid sequence in which amino acid residue 141 is isoleucine in a protein comprising 448 amino acid residues, which is a gene product of the human AD4 gene. (B) an amino acid sequence in which one or several amino acids have been deleted, substituted or added in the protein, and the isoleucine at the original amino acid sequence position 141 has an amino acid sequence not deleted by the deletion And a protein that causes Alzheimer's disease. [Selection figure] None |