| abstract |
A formulation comprising an antineoplastic agent such as temozolomide, which is water soluble and stable to lyophilization, long-term storage and reconstitution of a lyophilized formulation into an aqueous solution and / or Provide a suitable formulation. At least one antineoplastic agent or a pharmaceutically acceptable salt thereof, at least one aqueous diluent, and at least one solubility enhancer sufficient to sufficiently dissolve the antineoplastic agent. A pharmaceutical formulation comprising, wherein the dissolution enhancer is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine, or a mixture thereof, Is solved. [Selection figure] None |