abstract |
A recombinant retrovirus capable of transporting a vector construct to a susceptible target cell is provided. A replication-defective recombinant retrovirus having a vector structure, wherein the vector structure expresses a mitigation agent capable of inhibiting the function of a pathogenic substance in a cell infected by the retrovirus. The use of replication-defective recombinant retroviruses characterized in that they result in, as well as the use of replication-defective recombinant retroviruses in the manufacture of a medicament for reducing or eliminating unwanted or harmful immune responses. [Selection] Figure 1 |